Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
University of Alberta
$392,006.00
Molecular neuropathogenesis of HIV-associated neurocognitive disorders
FY 2010-11
Summary
We have recently shown that human immunodeficiency virus (HIV) type 1 infection causes HIV-associated neurocognitive disorders (HAND) despite receiving active HIV care in Canada. These disorders are defined by neurocognitive impairments, neuropsychiatric features and motor abnormalities. HAND is a burgeoning problem encountered in clinical care, which heralds a worsened survival rate among people with HIV/AIDS. Neurodegeneration (brain cell death) is the basis of HAND and is caused by the direct toxic effects of HIV proteins together with concurrent inflammation within the brain although the causative disease mechanisms remain uncertain. Herein, we will investigate the causes and new treatment strategies for HAND through analyses of clinical brain and blood specimens from our Alberta NeuroAIDS Cohort, novel cell culture and animal models developed in our laboratory.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
230964
Name
Power Christopher
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Molecular neuropathogenesis of HIV-associated neurocognitive disorders
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$392,006
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Clinical Cohort; Deep Sequencing; Hiv; Microrna; Nef; Neurodegeneration; Neuroinflammation; Neurotoxicity; Transgenic Mice; Vpr
Abstract
We have recently shown that human immunodeficiency virus (HIV) type 1 infection causes HIV-associated neurocognitive disorders (HAND) despite receiving active HIV care in Canada. These disorders are defined by neurocognitive impairments, neuropsychiatric features and motor abnormalities. HAND is a burgeoning problem encountered in clinical care, which heralds a worsened survival rate among people with HIV/AIDS. Neurodegeneration (brain cell death) is the basis of HAND and is caused by the direct toxic effects of HIV proteins together with concurrent inflammation within the brain although the causative disease mechanisms remain uncertain. Herein, we will investigate the causes and new treatment strategies for HAND through analyses of clinical brain and blood specimens from our Alberta NeuroAIDS Cohort, novel cell culture and animal models developed in our laboratory.
Competitiondate
201103
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Power, Christopher
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $392,006~ $0~
