Grant: Project Grant
University of Toronto
$749,700.00
Extracellular Vimentin Drives Periodontal Destruction
FY 2023-24
Summary
Many tissues in humans exhibit destruction and loss of function as a result of inflammatory diseases. Some of these diseases, like osteoarthritis, rheumatoid arthritis and a type of gum disease known as periodontitis, are of high prevalence, cause substantial pain and are associated with high treatment costs. These diseases also exhibit long-standing chronic inflammation that is interrupted by brief episodes during which there is rapid tissue destruction. In this application we examine one important mechanism by which a protein released from cells in chronic inflammation causes tissue destruction during brief episodes and we examine how this destructive mechanism can be inhibited to conserve tissue structure and function.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
499431
Name
McCulloch Christopher A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
Extracellular Vimentin Drives Periodontal Destruction
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$749,700
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Animal Model Of Disease; Calcium Signaling; Connective Tissue Destruction; Cytoskeleton; Inflammation; Intermediate Filaments; Matrix Metalloproteinases; Periodontal Diseases; Protein Secretion; Proteomics
Abstract
Many tissues in humans exhibit destruction and loss of function as a result of inflammatory diseases. Some of these diseases, like osteoarthritis, rheumatoid arthritis and a type of gum disease known as periodontitis, are of high prevalence, cause substantial pain and are associated with high treatment costs. These diseases also exhibit long-standing chronic inflammation that is interrupted by brief episodes during which there is rapid tissue destruction. In this application we examine one important mechanism by which a protein released from cells in chronic inflammation causes tissue destruction during brief episodes and we examine how this destructive mechanism can be inhibited to conserve tissue structure and function.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McCulloch, Christopher A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $749,700~ $0~
