Grant: Project Grant
University of Toronto
$1,005,975.00
The role of the iNeuron in reprogramming-mediated brain repair
FY 2020-21
Summary
Most brain injuries and disease result in the death of neurons. These are the cells that are responsible for sending and receiving brain signals. To restore function of these cells we have been trying to develop therapies that convert cells already in the brain into new neurons to replace those that are lost to injury or disease. We have previously shown that this type of reprogramming can lead to improvements in function after injury. However, we know little about these newly generated neurons. Are they like the neurons in our brain? Do they help our brain recovery from injury? Our study will answer these questions and help us understand if and how these newly generated neurons mediate the recovery in function.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
435186
Name
Faiz Maryam
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Systems & Circuits Neurosciences - A
Projecttitle
The role of the iNeuron in reprogramming-mediated brain repair
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$1,005,975
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Astrocytes; Cns; Direct Reprogramming; Patch-Seq; Stroke; Transgenic Animals
Abstract
Most brain injuries and disease result in the death of neurons. These are the cells that are responsible for sending and receiving brain signals. To restore function of these cells we have been trying to develop therapies that convert cells already in the brain into new neurons to replace those that are lost to injury or disease. We have previously shown that this type of reprogramming can lead to improvements in function after injury. However, we know little about these newly generated neurons. Are they like the neurons in our brain? Do they help our brain recovery from injury? Our study will answer these questions and help us understand if and how these newly generated neurons mediate the recovery in function.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Faiz, Maryam
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,005,975~ $0~
