Grant: Travel Awards - Institute Community Support

In the adult mammalian brain, stem-cells are still present in different regions and can give rise to new neurons, this phenomenon is called neurogenesis. One of the regions is the subventricular zone of the lateral ventricles. This neurogenesis plays a rôle in the olfaction and in brain repair mechanisms after an injury. However this neurogenesis decreases during aging. The major issue in the aging field is that the mechanisms underlying this decline in neurogenesis are still unclear. During my PhD, the main objective is to determine the different mechanisms that are responsible for the decrease in neurogenesis. In conclusion by identifying the different mechanisms altering the stem-cells functioning, we would ultimately be able to find therapeutic approches to restore their activity during aging and potentially, in neurodegenerative diseases.