Grant: Project Grant
McMaster University
$657,471.00
IL-8 produced by allergen-specific T cells plays a key role in the pathogenesis of allergic inflammation.
FY 2015-16
Summary
In an earlier study, using blood from allergic people, we examined a particular type of white blood cell (T cell) that recognizes and responds to proteins (allergens) that cause allergies. We looked at the genes that are switched on and switched off in these cells, before and after an effective treatment with a vaccine that we have developed to treat allergic disease. We found several interesting changes in the T cell genes after treatment, but one change stood out; this was the switching off of a gene that makes a protein called "IL-8". In the research that we would now like to undertake, we will define the role played by IL-8 in driving allergic reactions. We will also define the changes in other T cell genes that lead to the switching off of IL-8. Together, this information will tell us how allergic reactions occur and provide more opportunities to develop new treatments.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
344291
Name
Larche Mark
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
IL-8 produced by allergen-specific T cells plays a key role in the pathogenesis of allergic inflammation.
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$657,471
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Allergy; Asthma; Basophil; Cxcl8; Epitope; Il-8; Immunotherapy; Neutrophil; Peptide; T Cell
Abstract
In an earlier study, using blood from allergic people, we examined a particular type of white blood cell (T cell) that recognizes and responds to proteins (allergens) that cause allergies. We looked at the genes that are switched on and switched off in these cells, before and after an effective treatment with a vaccine that we have developed to treat allergic disease. We found several interesting changes in the T cell genes after treatment, but one change stood out; this was the switching off of a gene that makes a protein called "IL-8". In the research that we would now like to undertake, we will define the role played by IL-8 in driving allergic reactions. We will also define the changes in other T cell genes that lead to the switching off of IL-8. Together, this information will tell us how allergic reactions occur and provide more opportunities to develop new treatments.
Competitiondate
201603
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Larche, Mark; Tonti, Elena
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $657,471~ $0~
