Grant: Operating Grant

Elevated expression of members of a class of growth factor receptors known as the epidermal growth factor receptor (EGFR) family have been implicated as important determinants the induction of breast cancer. The major focus of this renewal application is assess the relative contribution of the different EGFR family members to various stages of breast cancer progression. To accomplish this we taken advantage of number of mouse models of human breast cancer and have used both biochemical and genetic approaches to functionally attenuate different members EGFR in the mammary epithelium. The results of these studies will provide important therapeutic targets to target breast cancer progression.