Grant: Project Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$780,300.00
To study the pathogenesis and its underlying mechanisms of an abnormally large Pol II pool size caused by a defective novel ARMC5-containing POLR2A-specific ubiquitin ligase
FY 2021-22
Summary
We recently found that a molecule called ARMC5 is part of an enzyme called ubiquitin ligase (E3). Its target is a molecule called POLR2A, which is involved in messenger RNA synthesis. This ligase will mark POLR2A for destruction. In mice and humans with ARMC5 mutations, POLR2A is accumulated. This is unhealthy, leading to many types of diseases in newborns and old individuals, such as spinal column deformation and enlarged adrenal glands.
In this project, we will try to understand how the accumulation of POLR2A due to ARMC5 mutation causes diseases.
Our study will enhance our knowledge regarding how this new E3 works and how its abnormality causes human diseases.
Department
Program
Project Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
450595
Name
Wu Jiangping
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Cell Biology - Disease
Projecttitle
To study the pathogenesis and its underlying mechanisms of an abnormally large Pol II pool size caused by a defective novel ARMC5-containing POLR2A-specific ubiquitin ligase
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$780,300
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Adrenal Gland Hyperplasia; Armc5; Neural Tube Defects; Pol Ii Pool Size; Polr2a (Rpb1); Protein Degradation; Rna Polymerase Ii (Pol Ii); Ubiquitin Ligase
Abstract
We recently found that a molecule called ARMC5 is part of an enzyme called ubiquitin ligase (E3). Its target is a molecule called POLR2A, which is involved in messenger RNA synthesis. This ligase will mark POLR2A for destruction. In mice and humans with ARMC5 mutations, POLR2A is accumulated. This is unhealthy, leading to many types of diseases in newborns and old individuals, such as spinal column deformation and enlarged adrenal glands.
In this project, we will try to understand how the accumulation of POLR2A due to ARMC5 mutation causes diseases.
Our study will enhance our knowledge regarding how this new E3 works and how its abnormality causes human diseases.
Competitiondate
202109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Wu, Jiangping
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $780,300~ $0~
