Grant: Operating Grant
University of Ottawa
$705,926.00
Targeting CaMKinase and Ca2+ Signaling in the Cardiovascular System
FY 2012-13
Summary
We have discovered a new set of proteins that are present in the heart which appear to be critical for translating the calcium signal to the contraction and relaxation machinery. These proteins belong to a well known family of protein kinases that are activated in response to changes in calcium concentration in the cell. These proteins are also important in relaying information to the genome of the heart and control activity of genes involved in the growth of the heart. We believe these proteins to be important targets in heart disease as their family members are deregulated in human heart failure.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
281344
Name
Tuana Balwant S
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - A: Cells and Tissues
Projecttitle
Targeting CaMKinase and Ca2+ Signaling in the Cardiovascular System
Programtype2
Operating Grants
Orgnameinp2
University of Ottawa
Cihramount2
$705,926
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Calcium Ions; Cardiovascular; Gene Expression; Microrna; Muscle Cells; Protein Kinases
Abstract
We have discovered a new set of proteins that are present in the heart which appear to be critical for translating the calcium signal to the contraction and relaxation machinery. These proteins belong to a well known family of protein kinases that are activated in response to changes in calcium concentration in the cell. These proteins are also important in relaying information to the genome of the heart and control activity of genes involved in the growth of the heart. We believe these proteins to be important targets in heart disease as their family members are deregulated in human heart failure.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Tuana, Balwant S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $705,926~ $0~
