Grant: Doctoral Research Award: Canada Graduate Scholarships
Queen's University (Kingston, Ontario)
$105,000.00
Exploring microRNA biomarkers and mechanisms of disease in neuroendocrine neoplasms
FY 2020-21
Summary
Neuroendocrine neoplasms (NENs) include diverse cancers arising in the digestive tract, lungs, regions of the brain, and more. Since NENs are less common than other cancers, they may be missed until patients have advanced stage disease that cannot be treated. The range of treatments for NENs is narrow and some treatments produce problematic side effects. We will investigate microRNAs (miRNAs), small molecules that negatively regulate gene expression, for their utility to diagnose NENs and understand the cancer development of NENs. By studying miRNAs, we expect to develop a simple blood test to improve the timeliness of NEN diagnosis. We also expect to learn about the molecular drivers of NEN development, which provide insight into new strategies to treat NENs.
Department
Program
Doctoral Research Award: Canada Graduate Scholarships
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
440032
Name
Nanayakkara Jinadari
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Doctoral Research Awards - A
Projecttitle
Exploring microRNA biomarkers and mechanisms of disease in neuroendocrine neoplasms
Programtype2
Studentship Programs
Orgnameinp2
Queen's University (Kingston, Ontario)
Cihramount2
$105,000
Cihrequipment2
$0
Programname2
Doctoral Research Award: Canada Graduate Scholarships
Keyworddelim
Biomarker Development; Chip-Sequencing; Graph Theory; Microrna; Molecular Mechanisms; Network Models; Neuroendocrine Neoplasms; Post-Transcriptional Gene Regulation; Rna-Based Therapeutics; Rna-Sequencing
Abstract
Neuroendocrine neoplasms (NENs) include diverse cancers arising in the digestive tract, lungs, regions of the brain, and more. Since NENs are less common than other cancers, they may be missed until patients have advanced stage disease that cannot be treated. The range of treatments for NENs is narrow and some treatments produce problematic side effects. We will investigate microRNAs (miRNAs), small molecules that negatively regulate gene expression, for their utility to diagnose NENs and understand the cancer development of NENs. By studying miRNAs, we expect to develop a simple blood test to improve the timeliness of NEN diagnosis. We also expect to learn about the molecular drivers of NEN development, which provide insight into new strategies to treat NENs.
Competitiondate
202011
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Nanayakkara, Jinadari
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $105,000~ $0~
