Grant: Project Grant
University of Manitoba
$573,752.00
Role of migratory DCs in HIV dissemination in vivo
FY 2017-18
Summary
The human immunodeficiency virus-1 (HIV-1) has infected more than 70 million people worldwide. The majority of new heterosexual HIV infections are women, yet how the virus spreads from the vaginal tissue to other parts of the body is not known. We have data supporting that HIV can be carried by migrating cells, and that preventing these cells from leaving the infected site can prevent HIV infection. Thus, it is important to identify which cell populations are able to transport HIV in order to design therapeutic drugs to block this mode of spread. In this proposal, we will test whether dendritic cells can actively transport virus within the body, and use microscopy techniques to understand how viruses are transmitted from one cell to another.
Department
Program
Project Grant
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
371478
Name
Murooka Thomas T
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Role of migratory DCs in HIV dissemination in vivo
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$573,752
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cell Migration; Cell-To-Cell Interaction; Dendritic Cells; Flourescent Hiv Reporter; Hiv Dissemination; Human Immunodeficiency Virus-1; Humanized Mice; Lymph Node; Multiphoton Intravital Microscopy; T Cells
Abstract
The human immunodeficiency virus-1 (HIV-1) has infected more than 70 million people worldwide. The majority of new heterosexual HIV infections are women, yet how the virus spreads from the vaginal tissue to other parts of the body is not known. We have data supporting that HIV can be carried by migrating cells, and that preventing these cells from leaving the infected site can prevent HIV infection. Thus, it is important to identify which cell populations are able to transport HIV in order to design therapeutic drugs to block this mode of spread. In this proposal, we will test whether dendritic cells can actively transport virus within the body, and use microscopy techniques to understand how viruses are transmitted from one cell to another.
Competitiondate
201709
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Murooka, Thomas T
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $573,752~ $0~
