Grant: Project Grant

It is well known that aberrant patterns of gene expression cause disease in many tissues. In the heart this is particularly important because the loss of cardiac muscle cells through inappropriate gene expression ultimately results in heart failure, a condition in which the heart cannot meet the blood supply demands of the body. In these studies we are attempting to understand the regulatory molecules that control these aberrant patterns of gene expression. Knowing what they are and how they function will lay the foundation of future drug discovery and treatment in cardiac disease.