Grant: Collaborative Research and Development Grants
Université de Sherbrooke
$148,000.00
Novel antibiotics for treatment of bovine mastitis / Nouveaux antibiotiques pour le traitement de la mammite bovine
FY 2015-16
Summary
Recently, our research led to the discovery of a new antibiotic target for bacteria. This new target is an RNA molecule with a regulatory function (a guanine riboswitch) apparently essential to certain bacteria causing infections in animals. We also identified a small drug-like molecule able to bind the guanine riboswitch and prevent expression of essential genes with subsequent bactericidal action. We further demonstrated the antibacterial activity of this compound in experimental therapies for Staphylococcus aureus intramammary infections (mastitis) in both mice and cows. With the help of Lilly Canada, Inc., and its animal health component (Elanco), the proposed R&D Project aims at optimizing the novel antibiotic for veterinary use in the dairy industry.
Program
Collaborative Research and Development Grants
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
460917-2013
Name nom
Malouin, Francois
Department département
Biologie
Organization id
68
Institution établissement
Université de Sherbrooke
Province en
Québec
Province fr
Québec
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2015
Competition year année de concours
2013
Award amount
148000
Program id
CRDPJ
Program name en
Collaborative Research and Development Grants
Program name fr
Subventions de recherche et développement coopérative
Group en
Research partnerships programs
Group fr
Programmes de partenariat
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
100
Area of application group en
Agriculture and primary food production
Area of application group fr
Agriculture et produits alimentaires primaires
Area of application en
Agriculture and primary food production
Area of application fr
Agriculture et produits alimentaires primaires
Research subject code
5200
Research subject group en
Microbiology
Research subject group fr
Microbiologie
Research subject en
Microbiology
Research subject fr
Microbiologie
Partie
2
Nb partie
3
Application title
Novel antibiotics for treatment of bovine mastitis / Nouveaux antibiotiques pour le traitement de la mammite bovine
Keyword
NSERC
Application summary
Recently, our research led to the discovery of a new antibiotic target for bacteria. This new target is an RNA molecule with a regulatory function (a guanine riboswitch) apparently essential to certain bacteria causing infections in animals. We also identified a small drug-like molecule able to bind the guanine riboswitch and prevent expression of essential genes with subsequent bactericidal action. We further demonstrated the antibacterial activity of this compound in experimental therapies for Staphylococcus aureus intramammary infections (mastitis) in both mice and cows. With the help of Lilly Canada, Inc., and its animal health component (Elanco), the proposed R&D Project aims at optimizing the novel antibiotic for veterinary use in the dairy industry.
