Grant: Discovery Grants Program - Individual
University of Lethbridge
$65,000.00
Hippocampus and memory: A systems level approach
FY 2023-24
Summary
The hippocampus is situated at the hub of a set of distributed cortical networks that represent movement and perceptual information. Amnesia is the most prominent effect of damage to or dysfunction of the hippocampus and most forms of human memory disorder involve the hippocampus. The current proposal examines in detail how the interactions between the hippocampus and other cortical networks establishes long-term memories. We use a combination of molecular markers of cellular activation imaged across the whole cortex, temporaryinactivation of hippocampus and connected regions using microinjections of inhibitors or designed receptors exclusively activated by designer drugs (DREADDs), and hippocampus-relevant memory tasks. We will discover exactly which types of information depend on the hippocampus and how the hippocampus modifies the functioning of the cortex through long-term interactions.
Program
Discovery Grants Program - Individual
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
RGPIN-2018-04724
Name nom
Sutherland, Robert
Department département
Neuroscience/Arts&Science
Organization id
12
Institution établissement
University of Lethbridge
Province en
Alberta
Province fr
Alberta
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2018
Award amount
65000
Program id
RGPIN
Program name en
Discovery Grants Program - Individual
Program name fr
Programme de subventions à la découverte - individuelles
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
1502
Committee name en
Biological Systems and Functions
Committee name fr
Systèmes et fonctions biologiques
Area of application code
1101
Area of application group en
Health, education and social services
Area of application group fr
Santé publique, éducation et services sociaux
Area of application en
Human health (including medically-related psychological research)
Area of application fr
Santé publique (y compris recherche psychologique liée à la médecine)
Research subject code
6400
Research subject group en
Life sciences research related to human health and disease
Research subject group fr
Life sciences research related to human health and disease
Research subject en
Sciences de la vie liées à la santé publique et aux maladies humaines
Research subject fr
Sciences de la vie liées à la santé publique et aux maladies humaines
Application title
Hippocampus and memory: A systems level approach
Keyword
consolidation; encoding; entorhinal cortex; episodic memory; hippocampus; immediate early genes; memory; memory retrieval; retrieval; retrosplenial cortex
Application summary
The hippocampus is situated at the hub of a set of distributed cortical networks that represent movement and perceptual information. Amnesia is the most prominent effect of damage to or dysfunction of the hippocampus and most forms of human memory disorder involve the hippocampus. The current proposal examines in detail how the interactions between the hippocampus and other cortical networks establishes long-term memories. We use a combination of molecular markers of cellular activation imaged across the whole cortex, temporaryinactivation of hippocampus and connected regions using microinjections of inhibitors or designed receptors exclusively activated by designer drugs (DREADDs), and hippocampus-relevant memory tasks. We will discover exactly which types of information depend on the hippocampus and how the hippocampus modifies the functioning of the cortex through long-term interactions.
