Grant: Project Grant
McGill University
$566,099.00
Identification, development and application of novel neuroserpin inhibitors to correct the NGF deficiency in the Alzheimer's disease pathology
FY 2023-24
Summary
In the brain of people affected by Alzheimer's disease there is a progressive loss of a brain neurotransmitter system which plays a key role in cognitive functions. The neurons involved in this system (called basal forebrain cholinergic neurons: BFCNs) require a molecule called NGF to maintain their health. In Alzheimer's the levels of NGF decrease, hence these neurons degenerate and deprive the brain of chemicals needed for memory and other cognitive functions. The purpose of the proposed study is to develop a pharmacological strategy to re-establish the supply of NGF to these neurons restoring their contributions to memory and cognitive mechanisms.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
490333
Name
Cuello A. Claudio G
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Biological and Clinical Aspects of Aging
Projecttitle
Identification, development and application of novel neuroserpin inhibitors to correct the NGF deficiency in the Alzheimer's disease pathology
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$566,099
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Alzheimer'S Disease; Basal Forebrain Cholinergic System; Cholinergic Neurons; Experimental Therapeutics; Nerve Growth Factor (Ngf); Neuroserpin; Ngf Metabolic Pathway; Small Molecule Inhibitor
Abstract
In the brain of people affected by Alzheimer's disease there is a progressive loss of a brain neurotransmitter system which plays a key role in cognitive functions. The neurons involved in this system (called basal forebrain cholinergic neurons: BFCNs) require a molecule called NGF to maintain their health. In Alzheimer's the levels of NGF decrease, hence these neurons degenerate and deprive the brain of chemicals needed for memory and other cognitive functions. The purpose of the proposed study is to develop a pharmacological strategy to re-establish the supply of NGF to these neurons restoring their contributions to memory and cognitive mechanisms.
Competitiondate
202309
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Cuello, A. Claudio G
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $566,099~ $0~
