Grant: Operating Grant - PA: Regional Partnership Program : Manitoba

We have previously measured several thousand host proteins and determined that a few hundred are up-regulated or down-regulated after cells are infected by reovirus. Our goals in this continuing project are to now determine the functional importance of these proteins. We will also focus more detailed follow-up studies on those few proteins (approximately 10) which are known to play key roles in a few critically important cellular pathways. This will provide us important information about how viruses manipulate cells and kill them, which should move us closer to using this virus as a beneficial anti-cancer treatment.