Grant: Canada Research Chairs
Université du Québec à Trois-Rivières
$50,000.00
Plant specialized metabolism
FY 2023-24
Summary
The Chair aims to generate omics and use systems biology to elucidate alkaloid biosynthesis in
order to reproduce alkaloid pathway in microalgea to enhance their production of pharmaceutical
alkaloids. Using omic approaches, the transriptome and metabolome of Amaryllidaceae plants will
be generated and used to identified candidate genes encoding enzymes involved in AA
biosynthetic pathway. Next, candidate genes witll be functionnaly characterized in vitro and in vivo
and inserted into microalgea for the reconstruction of the Amaryllidaceae alkaloid pathway.
Knowledge obtained will provide genetic tools for the production of valuable alkaloid in microalgea
or for the engineering of plant cultivars better able to produce these valuable alkaloids.
Program
Canada Research Chairs
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CRC-2018-00137
Name nom
Desgagné-Penix, Isabel
Department département
Chimie, biochimie et physique - Université du Québec à Trois-Rivières
Organization id
59
Institution établissement
Université du Québec à Trois-Rivières
Province en
Québec
Province fr
Québec
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2018
Award amount
50000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
10000
Research subject group en
The field of research available
Research subject group fr
The field of research available
Research subject en
Le domaine de recherche disponible
Research subject fr
Le domaine de recherche disponible
Field of research list codes
RDF10601;RDF10608
Field of research list names en
Biochemistry;Animal physiology
Field of research list names fr
Biochimie;Physiologie animale
Application title
Plant specialized metabolism
Keyword
plant biochemistry
specialized metabolism
alkaloids
; biosynthesis
metabolic engineering
synthetic biology
; microalgea
Application summary
The Chair aims to generate omics and use systems biology to elucidate alkaloid biosynthesis in
order to reproduce alkaloid pathway in microalgea to enhance their production of pharmaceutical
alkaloids. Using omic approaches, the transriptome and metabolome of Amaryllidaceae plants will
be generated and used to identified candidate genes encoding enzymes involved in AA
biosynthetic pathway. Next, candidate genes witll be functionnaly characterized in vitro and in vivo
and inserted into microalgea for the reconstruction of the Amaryllidaceae alkaloid pathway.
Knowledge obtained will provide genetic tools for the production of valuable alkaloid in microalgea
or for the engineering of plant cultivars better able to produce these valuable alkaloids.
