Grant: Project Grant
York University (Toronto, Ontario)
$921,825.00
Regulation of gene expression by the La and La-related proteins
FY 2023-24
Summary
Healthy cells have evolved a number of ways to respond to their environment and adapt to stresses. One critical way that cells respond to such cues is by controlling the cohort of proteins they synthesise, which allows the cell to adapt to new situations. However, dysregulation of of these responses can lead to diseases like cancer and neurodegeneration. One class of factors known to have an important function in the control of protein synthesis is the La and La-related proteins. Dysregulation of function of the La and La-related proteins has been linked extensively to cancer and infection by viruses, but we do not understand how. In this proposal, we will identify the genes that rely on these factors as well the ways in which they control gene expression. Our work will therefore lead to a substantial new understanding for many challenges to human health.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
489704
Name
Bayfield Mark A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Regulation of gene expression by the La and La-related proteins
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$921,825
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cellular Adaptations To Stress; Control Of Protein Translation; La And La-Related Proteins; Rna Binding Proteins; Rna Chaperones; Rna Processing; Rna Stability; Rna Structure/Function
Abstract
Healthy cells have evolved a number of ways to respond to their environment and adapt to stresses. One critical way that cells respond to such cues is by controlling the cohort of proteins they synthesise, which allows the cell to adapt to new situations. However, dysregulation of of these responses can lead to diseases like cancer and neurodegeneration. One class of factors known to have an important function in the control of protein synthesis is the La and La-related proteins. Dysregulation of function of the La and La-related proteins has been linked extensively to cancer and infection by viruses, but we do not understand how. In this proposal, we will identify the genes that rely on these factors as well the ways in which they control gene expression. Our work will therefore lead to a substantial new understanding for many challenges to human health.
Competitiondate
202309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Bayfield, Mark A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $921,825~ $0~
