Grant: Project Grant
McGill University
$1,044,226.00
TACAN is an ion channel essential for osteoarthritis pain
FY 2019-20
Summary
Osteoarthritis (OA) afflicts more than 10% of Canadians. The cardinal symptom of this disease is chronic pain at rest or during movement. Clinical and preclinical research have indicated that OA pain emanates from hyper-responsive pain-sensing fibers (also called nociceptors). Yet the mechanisms underlying this hypersensitivity remain unknown. We have previously demonstrated that a subtype of sensors expressed in nociceptors become sensitized during OA and are responsible for the pain symptoms. However, the identity of these sensors remained elusive. We have now identified a protein, named TACAN, that acts as a sensor for painful stimuli. The current proposal aims at taking a translational approach to determine whether TACAN is responsible for OA pain and could constitute a valuable therapeutic target for OA pain.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
420310
Name
Sharif-Naeini Reza
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
TACAN is an ion channel essential for osteoarthritis pain
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,044,226
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Electrophysiology; Inflammation; Ion Channels; Mechanotransduction; Nociceptor; Osteoarthritis; Pain; Patch Clamp
Abstract
Osteoarthritis (OA) afflicts more than 10% of Canadians. The cardinal symptom of this disease is chronic pain at rest or during movement. Clinical and preclinical research have indicated that OA pain emanates from hyper-responsive pain-sensing fibers (also called nociceptors). Yet the mechanisms underlying this hypersensitivity remain unknown. We have previously demonstrated that a subtype of sensors expressed in nociceptors become sensitized during OA and are responsible for the pain symptoms. However, the identity of these sensors remained elusive. We have now identified a protein, named TACAN, that acts as a sensor for painful stimuli. The current proposal aims at taking a translational approach to determine whether TACAN is responsible for OA pain and could constitute a valuable therapeutic target for OA pain.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sharif-Naeini, Reza
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,044,226~ $0~
