Grant: Operating Grant
Centre hospitalier de l'Université de Montréal (CHUM)
$711,334.00
Role of astrocytes in blood-brain barrier regulation and CNS immunity
FY 2008-09
Summary
The Blood-Brain Barrier (BBB) restrict the passage of noxious molecules and cells from the blood to the brain. In diseases
like Multiple Sclerosis (MS), the BBB fails to prevent entry of aggressive white blood cells (leukocytes) into the brain. These
leukocytes are thought to be the effectors of damage to brain cells. Our work focus on both the intact and damaged BBB and
its role on the development of inflammatory diseases directed to the brain. We intend to understand the molecular
mechanisms involved in the formation of a tight and impermeable BBB and to study the dysregulation of these mechanisms
in MS. As MS is the most prevalent neurological disorder of young adults in Canada and the first cause of permanent
handicap, our research can have a significant impact on the health status of thousands of young canadians.
Department
Program
Operating Grant
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
179067
Name
Prat Alexandre
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Systems & Circuits Neurosciences - A
Projecttitle
Role of astrocytes in blood-brain barrier regulation and CNS immunity
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$711,334
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Astrocytes; Blood Brain Barrier; Endothelium; Hedgehog; Neuro-Inflammation; Tight Junction Proteins
Abstract
The Blood-Brain Barrier (BBB) restrict the passage of noxious molecules and cells from the blood to the brain. In diseases
like Multiple Sclerosis (MS), the BBB fails to prevent entry of aggressive white blood cells (leukocytes) into the brain. These
leukocytes are thought to be the effectors of damage to brain cells. Our work focus on both the intact and damaged BBB and
its role on the development of inflammatory diseases directed to the brain. We intend to understand the molecular
mechanisms involved in the formation of a tight and impermeable BBB and to study the dysregulation of these mechanisms
in MS. As MS is the most prevalent neurological disorder of young adults in Canada and the first cause of permanent
handicap, our research can have a significant impact on the health status of thousands of young canadians.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Prat, Alexandre
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $711,334~ $0~
