Grant: Operating Grant
Université Laval
$796,579.00
Analysis of T cell reservoirs in visceral tissues of pathogenic and non-pathogenic primate models of lentiviral SIV infection
FY 2013-14
Summary
Aids disease is associated with a loss of efficiency of immune system, which is essential to control microbes, in particular viruses like HIV. The various effects of this virus have largely been studied in the blood. Much of the virus is however localized in deep tissues, which are impossible to study in humans for obvious ethical reasons. We then have to rely on animal models, in our case monkeys, because they develop a disease similar to that of humans. Our project is to decipher in this model how the virus that is responsible for the development of AIDS infects different organs, notably the gut and the spleen, and how it destroys the immune system.
The knowledge thus gained on AIDS pathology may not only allow us to propose new strategies to eradicate the virus in deep tissues, but it will also be very useful to the design of vaccines.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
292262
Name
Estaquier Jérôme
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Analysis of T cell reservoirs in visceral tissues of pathogenic and non-pathogenic primate models of lentiviral SIV infection
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$796,579
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Activation; Aids; Apoptosis; Genome Sequencing; Immunology; Pathiology; Primate; Siv
Abstract
Aids disease is associated with a loss of efficiency of immune system, which is essential to control microbes, in particular viruses like HIV. The various effects of this virus have largely been studied in the blood. Much of the virus is however localized in deep tissues, which are impossible to study in humans for obvious ethical reasons. We then have to rely on animal models, in our case monkeys, because they develop a disease similar to that of humans. Our project is to decipher in this model how the virus that is responsible for the development of AIDS infects different organs, notably the gut and the spleen, and how it destroys the immune system.
The knowledge thus gained on AIDS pathology may not only allow us to propose new strategies to eradicate the virus in deep tissues, but it will also be very useful to the design of vaccines.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Estaquier, Jérôme
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $796,579~ $0~
