Grant: Project Grant
University of Guelph
$956,250.00
Evaluating the efficacy of n-3 polyunsaturated fatty acids in mild traumatic brain injury in varsity athletes and mice
FY 2025-26
Summary
There is growing interest in the role of nutrition in the prevention and treatment of brain injury occurring through sport or accidents. Mild traumatic brain injuries commonly occur in many sports such as football, rugby, ice hockey, field hockey, soccer, volleyball, and basketball . Similarly, in daily living, slips and falls may result in mild brain injuries. Currently, there is growing interest in the use of omega-3 fatty acids to support brain health and reduce the effects of brain injury. However, long-term efficacy and mechanistic studies are needed to substantiate these benefits. Therefore, we propose to determine if intake of omega-3 fatty acids mitigate effects of brain injury in varsity athletes over multiyear years of play. Furthermore, we will investigate mechanisms of action such as anti-inflammatory effects in a mouse model of brain injury.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
534249
Name
Ma David W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Nutrition, Food & Health
Projecttitle
Evaluating the efficacy of n-3 polyunsaturated fatty acids in mild traumatic brain injury in varsity athletes and mice
Programtype2
Operating Grants
Orgnameinp2
University of Guelph
Cihramount2
$956,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Ala; Dha; Epa; Fish Oil; Mild Traumatic Brain Injury; Mouse; N-3 Polyunsaturated Fatty Acids; Nutrition; Plant-Based; Varsity
Abstract
There is growing interest in the role of nutrition in the prevention and treatment of brain injury occurring through sport or accidents. Mild traumatic brain injuries commonly occur in many sports such as football, rugby, ice hockey, field hockey, soccer, volleyball, and basketball . Similarly, in daily living, slips and falls may result in mild brain injuries. Currently, there is growing interest in the use of omega-3 fatty acids to support brain health and reduce the effects of brain injury. However, long-term efficacy and mechanistic studies are needed to substantiate these benefits. Therefore, we propose to determine if intake of omega-3 fatty acids mitigate effects of brain injury in varsity athletes over multiyear years of play. Furthermore, we will investigate mechanisms of action such as anti-inflammatory effects in a mouse model of brain injury.
Competitiondate
202509
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ma, David W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $956,250~ $0~
