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Grant: Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives

The Governing Council of the University of Toronto

$100,000.00

Exploration of non-viral delivery of genetic material for immunotherapy for integration with microfluidics

FY 2021-22 · 2021-07-01

Summary
The goal of this project is to explore different non-viral technologies for precision targeting of gene therapies that could be deployed for different molecular targets and diseases. These include electroporation, lipid/liposomal nanoparticles, and cationic polymer nanoparticles. These methods will be tested for their suitability to integrate with immunotherapy, and one will be down-selected for value with microfluidics at the end of this project.
Program
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Location
Toronto|Toronto, Ontario, Canada
Recipient Type
Academia
Business Number
108162330
Type
Grant
Source
Proactive Disclosure - Grants and Contributions

As published

Agreement End Date
2022-06-30
Agreement Number
973723
Agreement Start Date
2021-07-01
Agreement Title
Exploration of non-viral delivery of genetic material for immunotherapy for integration with microfluidics
Agreement Title (French)
Administration de matériel génétique de source non virale en immunothérapie, en vue d’intégrer cette technique à la microfluidique
Agreement Type
Grant
Agreement Value
$100,000.00
Amendment Number
0
Description
The goal of this project is to explore different non-viral technologies for precision targeting of gene therapies that could be deployed for different molecular targets and diseases. These include electroporation, lipid/liposomal nanoparticles, and cationic polymer nanoparticles. These methods will be tested for their suitability to integrate with immunotherapy, and one will be down-selected for value with microfluidics at the end of this project.
Description (French)
Dans ce projet, on explorera diverses techniques non virales pour cibler avec précision des gènes dans le cadre d’un traitement génique, mais pouvant s’appliquer à d’autres objectifs moléculaires ou maladies. L’électroporation, les nanoparticules de lipides ou de liposomes et les nanoparticules cationiques de polymères en font partie. On vérifiera si ces techniques peuvent se combiner à l’immunothérapie et, à la fin du projet, on en choisira une pour voir si elle peut être intégrée efficacement à la microfluidique.
Expected Results
In the short term, anticipated outcomes will be strengthened collaborations across industry, academia, and government to support research excellence. In the medium term, anticipated outcomes will be the development of new and potentially disruptive technologies with collaborators. In the long term, find collaborative solutions to public policy challenges and create stronger innovation systems.
Expected Results (French)
À court terme, les résultats prévus seront des collaborations renforcées entre l'industrie, le milieu universitaire et le gouvernement pour soutenir l'excellence en recherche. À moyen terme, les résultats attendus seront le développement de nouvelles technologies potentiellement perturbatrices avec des collaborateurs. À long terme, trouver des solutions collaboratives aux défis des politiques publiques et créer des systèmes d'innovation plus solides.
Federal Riding
University–Rosedale
Federal Riding (French)
University–Rosedale
Federal Riding Number
35110
NAICS Code
541710 - R&D in the physical, engineering and life sciences
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Collaborative Science, Technology and Innovation Program - Collaborative R&D Initiatives
Program Name (French)
Programme de collaboration en science, en technologie et en innovation - Initiatives de collaboration en R-D
Program Purpose
Collaborate on multiparty research and development programs to catalyze transformative, high-risk, high-reward research with the potential for game-changing scientific discoveries and technological breakthroughs in priority areas.
Program Purpose (French)
Collaborer à des programmes multipartites de recherche-développement dans le but de profiter de la synergie entre la recherche transformatrice à haut risque et à haut rendement et le potentiel de découvertes scientifiques et de percées technologiques révolutionnaires dans des secteurs d’intervention prioritaires.
Recipient Business Number
108162330
Recipient City
Toronto|Toronto
Recipient Country
CA
Recipient Legal Name
The Governing Council of the University of Toronto
Recipient Postal Code
M5S 1S8
Recipient Province or Territory
ON
Recipient Type
S
Reference Number
172-2021-2022-Q1-973723
The Governing Council of the University of Toronto -… | Canada Spends