Grant: CIHR Fellowship
Lakehead University (Thunder Bay, Ontario)
$90,000.00
Regulation of vascular endothelial cell bioenergetics by H2S in health and under oxidative stress
FY 2012-13
Summary
Recent work has demonstrated that the rotten-egg gas, hydrogen sulfide (also known as "sewer gas" or "swamp gas") is produced by our cells and tissues, and regulates the metabolism and function of various cells including endothelial cells that form a thin layer of the inner wall of our blood vessels. Endothelial cells play a critical role in controlling blood flow and the integrity of blood vessels. The current project, based on multiple lines of new discoveries, will investigate the role of hydrogen sulfide in the alterations in endothelial metabolism and blood flow under healthy conditions, and in two models of blood vessel diseases; high blood pressure and atherosclerosis. We will study how the enzymes that produce hydrogen sulfide are moving inside the cell controlling the cellular production and utilization of energy and the way the cell can survive or die during cardiovascular diseases. With this project, Dr. Katalin Módis (a young Ph.D. pharmacist who has received specialized training in hydrogen sulfide biology at the University of Texas) will have the opportunity to join Lakehead University, Canada, to learn and to conduct cutting-edge studies with Dr. Rui Wang, a pioneer and leader of hydrogen sulfide biological research. The results of our studies will directly lead to the formulation of rational therapeutic concepts and are fundamentally relevant for multiple vascular diseases.
Department
Program
CIHR Fellowship
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
278990
Name
Modis Katalin
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Regulation of vascular endothelial cell bioenergetics by H2S in health and under oxidative stress
Programtype2
Fellowship Programs
Orgnameinp2
Lakehead University (Thunder Bay, Ontario)
Cihramount2
$90,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Atherosclerosis; Bioenergetics; Cardiovascular; Endothelium; Hydrogen Sulfide; Hypertension; Ion Channels; Mitochondria; Oxidative Stress; Redox Signaling
Abstract
Recent work has demonstrated that the rotten-egg gas, hydrogen sulfide (also known as "sewer gas" or "swamp gas") is produced by our cells and tissues, and regulates the metabolism and function of various cells including endothelial cells that form a thin layer of the inner wall of our blood vessels. Endothelial cells play a critical role in controlling blood flow and the integrity of blood vessels. The current project, based on multiple lines of new discoveries, will investigate the role of hydrogen sulfide in the alterations in endothelial metabolism and blood flow under healthy conditions, and in two models of blood vessel diseases; high blood pressure and atherosclerosis. We will study how the enzymes that produce hydrogen sulfide are moving inside the cell controlling the cellular production and utilization of energy and the way the cell can survive or die during cardiovascular diseases. With this project, Dr. Katalin Módis (a young Ph.D. pharmacist who has received specialized training in hydrogen sulfide biology at the University of Texas) will have the opportunity to join Lakehead University, Canada, to learn and to conduct cutting-edge studies with Dr. Rui Wang, a pioneer and leader of hydrogen sulfide biological research. The results of our studies will directly lead to the formulation of rational therapeutic concepts and are fundamentally relevant for multiple vascular diseases.
Competitiondate
201302
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Modis, Katalin
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $90,000~ $0~
