Grant: Project Grant

Proteins are macromolecules that carry out most tasks within cells. Abnormal levels of proteins or their dysfunction are linked to many human diseases, including outcome of viral infections. The process of turning genetic information into proteins, known as messenger RNA (mRNA) translation, is carefully controlled to manage accurate protein production. A key part of this control involves small RNA molecules called microRNAs (miRNAs), which attach to mRNAs and block them from making proteins. Our lab studies the important components involved in this process and how they affect protein production. The details of how this process works are still not fully understood. The goal of this proposal is to investigate the proteins that control mRNA translation and how they impact health and disease. By understanding how cells control protein production, we hope to identify new means to treat diseases.