Grant: Operating Grant
University of Alberta
$637,052.00
Regulation of CRTh2 and its role in allergic disease
FY 2010-11
Summary
Allergic diseases such as asthma are mediated by a number of cell types, particularly T helper type 2 (Th2) cells and eosinophils. Both these cell types express a protein called CRTh2, which helps them enter the site of allergic inflammation, such as the lung, nose or skin. CRTh2 also regulates the production of pro-allergy mediators like the Th2 cytokines IL-4, IL-5 and IL-13. This proposal is focused on understanding expression of CRTh2. Since genetic variation in CRTh2 is associated with higher risk of developing allergic asthma, we will also examine whether these single changes in DNA sequence change expression of CRTh2 and/or are more frequent in certain types of asthma.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
211750
Name
Cameron Lisa E
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Regulation of CRTh2 and its role in allergic disease
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$637,052
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Allergy; Cell Culture/Transfection; Functional Genomics; Gene Regulation; Human Th2; Single Nucleotide Polymorphism
Abstract
Allergic diseases such as asthma are mediated by a number of cell types, particularly T helper type 2 (Th2) cells and eosinophils. Both these cell types express a protein called CRTh2, which helps them enter the site of allergic inflammation, such as the lung, nose or skin. CRTh2 also regulates the production of pro-allergy mediators like the Th2 cytokines IL-4, IL-5 and IL-13. This proposal is focused on understanding expression of CRTh2. Since genetic variation in CRTh2 is associated with higher risk of developing allergic asthma, we will also examine whether these single changes in DNA sequence change expression of CRTh2 and/or are more frequent in certain types of asthma.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Cameron, Lisa E
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $637,052~ $0~
