Grant: Project Grant
University of Manitoba
$1,139,850.00
Role of mucosal neutrophils in driving HIV/HPV infection and disease progression
FY 2024-25
Summary
The immune system of the lower female genital tract plays an important role in maintaining reproductive health, but can also contribute to disease. While a number of biological and genetic factors can control the immune system, bacteria that live in the vagina are important players in regulating the immune system, and at times, can also lead to disease. In this research proposal, we will focus on specific bacteria that are linked to inflammatory disease in the lower female genital tract, and identify the immune cells that further exacerbate this disease process. We will use animal disease model to better understand how this inflammatory process increases HIV and HPV infection. The overall goal is to define why some individuals are more prone to sexually transmitted infections (STIs), and to test drug candidates that can lower acquisition risk.
Department
Program
Project Grant
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
510189
Name
Murooka Thomas T
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Role of mucosal neutrophils in driving HIV/HPV infection and disease progression
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$1,139,850
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacterial Vaginosis; Hiv-1; Inflammation; Microscopy; Mouse Models Of Infection; Neutrophils; Papillmovirus; T Cells; Vaginal Mucosa
Abstract
The immune system of the lower female genital tract plays an important role in maintaining reproductive health, but can also contribute to disease. While a number of biological and genetic factors can control the immune system, bacteria that live in the vagina are important players in regulating the immune system, and at times, can also lead to disease. In this research proposal, we will focus on specific bacteria that are linked to inflammatory disease in the lower female genital tract, and identify the immune cells that further exacerbate this disease process. We will use animal disease model to better understand how this inflammatory process increases HIV and HPV infection. The overall goal is to define why some individuals are more prone to sexually transmitted infections (STIs), and to test drug candidates that can lower acquisition risk.
Competitiondate
202409
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Murooka, Thomas T
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,139,850~ $0~
