Grant: Project Grant
McGill University
$1,025,100.00
Structural basis of Tn7 site-directed targeting
FY 2022-23
Summary
Almost half of our genome is derived from DNA elements that, at some point, moved from one site to another. DNA elements with the ability to move are called transposons. In humans, transposons are involved in neuronal development and cause many debilitating diseases. In bacteria, they drive evolution, fitness and the spread of drug resistance. DNA transposons can also be harnessed for genetic engineering purposes. We study how the bacterial Tn7 transposon, which is particularly efficient at spreading in all environments, targets DNA and how it could be used to develop genetic tools.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
478124
Name
Guarne Alba
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Structural basis of Tn7 site-directed targeting
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$1,025,100
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cryo-Electron Microscopy; Dna Replication; Dna Transposition; Genetic Engineering; Protein-Dna Interactions; Protein-Protein Interactions; Small-Angle X-Ray Scattering; X-Ray Crystallography
Abstract
Almost half of our genome is derived from DNA elements that, at some point, moved from one site to another. DNA elements with the ability to move are called transposons. In humans, transposons are involved in neuronal development and cause many debilitating diseases. In bacteria, they drive evolution, fitness and the spread of drug resistance. DNA transposons can also be harnessed for genetic engineering purposes. We study how the bacterial Tn7 transposon, which is particularly efficient at spreading in all environments, targets DNA and how it could be used to develop genetic tools.
Competitiondate
202303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Guarne, Alba
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,025,100~ $0~
