Grant: Emerging Team Grant: From Genes to Proteins, Cells, Tissues and Patients - LOI

Protein palmitoylation has recently emerged as a dynamic posttranslational modification critical for proper cellular trafficking. Our recent studies show that defects in palmitoylation are associated with dysfunction in Huntington Disease. We will effectively explore this process by using our novel proteomic technology to define defects in palmitoylation and their relation to HD. The discovery of enzymes that add or remove palmitate will be important for the identification of small molecule inhibitors that target these enzymes and the development of therapeutic tools. This CIHR Team brings together investigators who have made landmark discoveries in the field, including description of the palmitoyl proteome, and the first demonstration of altered palmitoylation in Huntington Disease.