Grant: Project Grant
York University (Toronto, Ontario)
$722,926.00
Investigating novel mechanisms of lipocalin-2 mediated cardiac dysfunction and their translational therapeutic potential
FY 2018-19
Summary
Many reports have established a correlation between obesity and cardiovascular complications such as heart failure. A causative role of obesity, and the accompanying diabetes, is well known. Heart failure is a progressive problem which occurs due to changes in the structure and function of the heart, yet the precise mechanisms responsible for regulating these changes in obesity remain to be determined. Given the escalation in the occurrence of obesity it is imperative to focus on understanding the mechanisms linking excess fat tissue to alterations in the structure and function of the heart to help prevent heart failure and potentially enhance our understanding of how to protect against progression of heart failure.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
401512
Name
Sweeney Gary
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cardiovascular System - A: Cells and Tissues
Projecttitle
Investigating novel mechanisms of lipocalin-2 mediated cardiac dysfunction and their translational therapeutic potential
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$722,926
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antibody; Autophagy; Cardiac Dysfunction; Cell Biology; Heart Failure; Inflammation; Knockdown; Knockout; Lipocalin-2; Neutralization
Abstract
Many reports have established a correlation between obesity and cardiovascular complications such as heart failure. A causative role of obesity, and the accompanying diabetes, is well known. Heart failure is a progressive problem which occurs due to changes in the structure and function of the heart, yet the precise mechanisms responsible for regulating these changes in obesity remain to be determined. Given the escalation in the occurrence of obesity it is imperative to focus on understanding the mechanisms linking excess fat tissue to alterations in the structure and function of the heart to help prevent heart failure and potentially enhance our understanding of how to protect against progression of heart failure.
Competitiondate
201903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sweeney, Gary
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $722,926~ $0~
