Grant: Project Grant

In Parkinson's Disease, a protein called alpha-synuclein forms aggregates that are toxic are result in the death of brain cells. We have discovered a new way by which cells control the folding of proteins, to avoid formation of toxic aggregates. We will explore how this new pathway that we call the "cytosolic unfolded protein response" or cUPR can inhibit the formation of these aggregates and also importantly their clearance. This could lead to the development of novel therapeutic avenues against Parkinson's disease.