Grant: Operating Grant
University of Toronto
$622,335.00
Wnt signalling circuitries in development and cancer.
FY 2011-12
Summary
During development, Wnt proteins control cell fate determination, cell proliferation as well as directed cell movement. We have identified new proteins important for these processes
during development and in cancer cells. Using different animal models and cell biological assays we propose to characterize the function of these proteins. This proposal will help continue understand the intracellular signalling pathways controlled by Wnt proteins and intend to test the efficiency of synthetic antibodies as potential treatment for metastatic breast cancer.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
253421
Name
Angers Stephane
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
Wnt signalling circuitries in development and cancer.
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$622,335
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Growth Factor; Metastasis; Planar Cell Polarity; Proteomics; Synthetic Antibodies; Wnt Signalling
Abstract
During development, Wnt proteins control cell fate determination, cell proliferation as well as directed cell movement. We have identified new proteins important for these processes
during development and in cancer cells. Using different animal models and cell biological assays we propose to characterize the function of these proteins. This proposal will help continue understand the intracellular signalling pathways controlled by Wnt proteins and intend to test the efficiency of synthetic antibodies as potential treatment for metastatic breast cancer.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Angers, Stephane
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $622,335~ $0~
