Grant: Operating Grant
University of Toronto
$478,008.00
Defining the clinical and immune causes of disproportionately high HIV levels in semen.
FY 2010-11
Summary
Globally most HIV is transmitted through the semen of an infected man. However, virus levels in semen are very variable and difficult to predict, even if a man is taking effective HIV medications and has an undetectable level of HIV in the blood. We propose to expand a productive and long-standing research collaboration within the Toronto HIV community to understand this phenomenon better. Specifically, we will examine how semen HIV levels are affected by local immune factors, different HIV medications and other bacteria/viruses that may be present in semen. We believe that this work will lead directly to new strategies to reduce or prevent HIV sexual transmission.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
226076
Name
Kaul Rupert
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
Defining the clinical and immune causes of disproportionately high HIV levels in semen.
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$478,008
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Antiretroviral Therapy; Cohort Studies; Flow Cytometry; Hiv Transmission; Microbiome; Mucosal Immunology; Pharmacokinetics; Semen
Abstract
Globally most HIV is transmitted through the semen of an infected man. However, virus levels in semen are very variable and difficult to predict, even if a man is taking effective HIV medications and has an undetectable level of HIV in the blood. We propose to expand a productive and long-standing research collaboration within the Toronto HIV community to understand this phenomenon better. Specifically, we will examine how semen HIV levels are affected by local immune factors, different HIV medications and other bacteria/viruses that may be present in semen. We believe that this work will lead directly to new strategies to reduce or prevent HIV sexual transmission.
Competitiondate
201103
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Kaul, Rupert
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $478,008~ $0~
