Grant: Operating Grant
Sunnybrook Research Institute (Toronto, Ontario)
$614,115.00
The role of glypicans in the regulation of hedgehog signaling
FY 2008-09
Summary
Glypicans are proteins that regulate the activity of various families of growth factors including Hedgehogs. The activity of these growth factors is frequently altered in cancer and other genetic diseases. The goal of this project is to investigate the molecular mechanisms by which the various glypicans regulate the activity of Hedeghogs. We expect that a better understanding of the role of glypicans in the regulation of the activity of Hedgehogs will facilitate the development of therapies that target such growth factors in cancer and other genetic diseases.
Department
Program
Operating Grant
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
180078
Name
Filmus Jorge E
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Molecular & Cellular Biology of Cancer
Projecttitle
The role of glypicans in the regulation of hedgehog signaling
Programtype2
Operating Grants
Orgnameinp2
Sunnybrook Research Institute (Toronto, Ontario)
Cihramount2
$614,115
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Glypicans; Hedgehog; Ovarian Cancer; Rhabdomyosarcoma
Abstract
Glypicans are proteins that regulate the activity of various families of growth factors including Hedgehogs. The activity of these growth factors is frequently altered in cancer and other genetic diseases. The goal of this project is to investigate the molecular mechanisms by which the various glypicans regulate the activity of Hedeghogs. We expect that a better understanding of the role of glypicans in the regulation of the activity of Hedgehogs will facilitate the development of therapies that target such growth factors in cancer and other genetic diseases.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Filmus, Jorge E
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $614,115~ $0~
