Grant: Project Grant
Université Laval
$1,039,250.00
Cortical GABAergic control in the comorbidity of chronic pain and mood disorders
FY 2024-25
Summary
Pain is both a sensory and emotional experience with a negative impact on the quality of life and a huge socio-economic cost when it becomes chronic. Chronic pain is not simply a sensory disorder, but a neurological disease accompanied by affective dysregulations that have a profound impact on mental health. Epidemiological studies report that 50% of overall chronic pain patients meet diagnostic criteria for major depressive disorders. The neurobiological mechanisms linking chronic pain to mood disorders are still not fully understood. We have uncovered indications that a loss of inhibitory control in some regions of the brain may underlie the mood disorder comorbidity to chronic pain. The proposed project will aim to identify the molecular mechanisms responsible for this loss of inhibitory control. The outcome of the project will help identify potential treatment strategies of chronic pain and its emotional consequences.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
510164
Name
De Koninck Yves
Region
Québec
Country
Canada
Orgtype
Research Institution; Institution Paid
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - C: Behavioural Studies, Neuroscience and Cognition
Projecttitle
Cortical GABAergic control in the comorbidity of chronic pain and mood disorders
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$1,039,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Anterior Cingulate Cortex; Anxio-Depressive Behaviour; Behavioural Assesment; Chronic Pain; Electrophysiology; Gaba; Glutamate; Inhibition; Optogenetics; Sodium Channels
Abstract
Pain is both a sensory and emotional experience with a negative impact on the quality of life and a huge socio-economic cost when it becomes chronic. Chronic pain is not simply a sensory disorder, but a neurological disease accompanied by affective dysregulations that have a profound impact on mental health. Epidemiological studies report that 50% of overall chronic pain patients meet diagnostic criteria for major depressive disorders. The neurobiological mechanisms linking chronic pain to mood disorders are still not fully understood. We have uncovered indications that a loss of inhibitory control in some regions of the brain may underlie the mood disorder comorbidity to chronic pain. The proposed project will aim to identify the molecular mechanisms responsible for this loss of inhibitory control. The outcome of the project will help identify potential treatment strategies of chronic pain and its emotional consequences.
Competitiondate
202409
Approvedterm2
5 yrs 0 mth
Pinamesdelim
De Koninck, Yves; Paquet, Marie-Eve; Yalcin-Christmann, Ipek
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,039,250~ $0~
