Grant: Project Grant
University of Toronto
$868,276.00
The role of NOD2 in intestinal regeneration following injury
FY 2021-22
Summary
Mutations in the gene NOD2 are linked to the development of the inflammatory bowel disease, Crohn's disease (CD). Approximately 1 in 250 people have CD in Canada and these individuals suffer from relapsing intestinal inflammation that causes a great deal of pain and often requires surgery. Currently there are treatments that calm the inflammation but no cure. Our preliminary work has suggested that NOD2 is involved in helping the intestine repair after injury. Our plan to is understand how NOD2 promotes this response, and in patients with CD, how we can use this knowledge to develop novel strategies to target pathways that initiate intestinal repair.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
445536
Name
Philpott Dana J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
The role of NOD2 in intestinal regeneration following injury
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$868,276
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Crohn'S Disease; Intestinal Regeneration; Microbiota; Nod2
Abstract
Mutations in the gene NOD2 are linked to the development of the inflammatory bowel disease, Crohn's disease (CD). Approximately 1 in 250 people have CD in Canada and these individuals suffer from relapsing intestinal inflammation that causes a great deal of pain and often requires surgery. Currently there are treatments that calm the inflammation but no cure. Our preliminary work has suggested that NOD2 is involved in helping the intestine repair after injury. Our plan to is understand how NOD2 promotes this response, and in patients with CD, how we can use this knowledge to develop novel strategies to target pathways that initiate intestinal repair.
Competitiondate
202104
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Philpott, Dana J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $868,276~ $0~
