Grant: Operating Grant
University of British Columbia
$684,420.00
Endothelial heparanase regulation of cardiac metabolism
FY 2013-14
Summary
The diabetic heart uses fatty acid exclusively as an energy resource for maintaining its activities. How the heart switches from using glucose to fatty acid is a swift and sophisticated process. Lipoprotein lipase (LPL) and vascular endothelial growth factor (VEGF) are considered to play important roles in this metabolic switching, with LPL providing these fats and VEGF helping with transport. In this proposal, we have designed experiments to examine how the endothelial cell, a "first-responder" to hyperglycemia (by secreting heparanase), communicates with the underlying cardiomyocyte (which releases LPL and VEGF). As this cross-talk is expected to facilitate increased FA delivery to, and utilization by, the cardiomyocyte, data obtained from these studies should assist in devising new therapeutic strategies to prevent or delay diabetic heart disease.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
289700
Name
Rodrigues Brian B
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Endothelial heparanase regulation of cardiac metabolism
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$684,420
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cardiac Metabolism; Heparanase; Lipoprotein Lipase; Lipotoxicity; Vegf
Abstract
The diabetic heart uses fatty acid exclusively as an energy resource for maintaining its activities. How the heart switches from using glucose to fatty acid is a swift and sophisticated process. Lipoprotein lipase (LPL) and vascular endothelial growth factor (VEGF) are considered to play important roles in this metabolic switching, with LPL providing these fats and VEGF helping with transport. In this proposal, we have designed experiments to examine how the endothelial cell, a "first-responder" to hyperglycemia (by secreting heparanase), communicates with the underlying cardiomyocyte (which releases LPL and VEGF). As this cross-talk is expected to facilitate increased FA delivery to, and utilization by, the cardiomyocyte, data obtained from these studies should assist in devising new therapeutic strategies to prevent or delay diabetic heart disease.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Rodrigues, Brian B
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $684,420~ $0~
