Grant: Team Grant: The Canadian Cannabis and Brain Health Consortium

Cannabis use is common in Canada, and the drug is stronger than it used to be. It's really important to understand how cannabis affects the brain, especially since heavy use might change the way people feel pleasure, rewards and motivation. This study will look at cannabis use in a group of Canadian adults between the ages of 19-60 that represents the general population. We will also collect information from 100 Canadians who report consuming cannabis every day or almost every day. In total 400 Canadian adults will participate. Each person will have two brain scans, 12 months apart, which will examine the brain's response when making choices about cannabis or other types of rewards. Another important goal of the study includes exploring how different chemicals in cannabis affect the body and the brain. This will be done by testing urine samples to measure cannabis-related substances. All together, this research will help us better understand how changes in the brain and everyday behaviours like motivation, choices and reactions to rewards might relate to changes in cannabis use over time, such as starting, increasing, or cutting back.