Grant: Operating Grant
Ottawa Hospital Research Institute
$692,730.00
Differential role of myogenic regulatory factors in establishing muscle-specific gene expression
FY 2009-10
Summary
Myogenin is a regulator of gene expression that is critically required for muscle formation. However, the mechanism by which this important protein mediates its role in muscle development is not well established. Using technologies that allow us to determine the other cellular proteins that specifically associate with myogenin, our work will determine how this critical factor decides which genes to turn on in muscle cells. The knowledge gained from these studies of myogenin function will facilitate the development of novel therapies to treat muscular dystrophy.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
200789
Name
Dilworth Jeffrey J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - B
Projecttitle
Differential role of myogenic regulatory factors in establishing muscle-specific gene expression
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$692,730
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Coactivators; Gene Expression; In Vitro Transcription; Muscle Differentiation; Proteomics; Transcription Factor
Abstract
Myogenin is a regulator of gene expression that is critically required for muscle formation. However, the mechanism by which this important protein mediates its role in muscle development is not well established. Using technologies that allow us to determine the other cellular proteins that specifically associate with myogenin, our work will determine how this critical factor decides which genes to turn on in muscle cells. The knowledge gained from these studies of myogenin function will facilitate the development of novel therapies to treat muscular dystrophy.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Dilworth, Jeffrey J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $692,730~ $0~
