Grant: CCI Applied Research and Development Grants
Collège La Cité
$40,000.00
Development of a robust polymerase chain reaction method to genotype three key genes attributed to Alzheimer's Disease risk using saliva
FY 2024-25
Summary
Alzheimer’s Disease (AD) accounts for 60-80% of cases of dementia in people over 65 years of age and affects over 50 million people worldwide and is expected to affect at least 150 million by 2050. Three risk genes, that were identified with strong association with late onset AD, are the topic of this research study - APOE, ABCA7 and PICALM6. Knowledge of the status of individuals at specific loci of these genes is useful in devising precision nutrition and other interventions that might contribute to preventing the development of AD. The intention is to streamline earlier diagnosis of AD which effectively leads to improved patient outcomes following pharmaceutical interventions. In developing this innovative technology to detect AD risk genes rapidly and accurately, revolutionizing the diagnostic process for the at-risk population.
Program
CCI Applied Research and Development Grants
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CCARD-2023-00571
Name nom
Bamji-Mirza, Michelle
Department département
Centre d'accès à la technologie en bio-innovation - Bureau de recherche et de l'innovation - La Cité collégiale
Organization id
28248
Institution établissement
Collège La Cité
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2023
Award amount
40000
Program id
CCARD
Program name en
CCI Applied Research and Development Grants
Program name fr
ICC Subventions de recherche et développement appliquée
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
nan
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Non disponible
Research subject en
Not available
Research subject fr
Non disponible
Field of research list codes
RDF3030204
Field of research list names en
Prevention, treatment and support of youth health
Field of research list names fr
Prévention, traitements et soutien de la santé des jeunes
Socioeconomic objective list codes
RDS10703
Socioeconomic objective list names en
Public health (except specific population health)
Socioeconomic objective list names fr
Santé publique (sauf la santé de populations précises)
Application title
Development of a robust polymerase chain reaction method to genotype three key genes attributed to Alzheimer's Disease risk using saliva
Keywords
Alzheimer’s Disease ; Dementia; Biomarkers; Heritability; Genetic analysis; Point-of-care device ; PCR; Single Nucleotide Variant ; Single Nucleotide Polymorphisms
Application summary
Alzheimer’s Disease (AD) accounts for 60-80% of cases of dementia in people over 65 years of age and affects over 50 million people worldwide and is expected to affect at least 150 million by 2050. Three risk genes, that were identified with strong association with late onset AD, are the topic of this research study - APOE, ABCA7 and PICALM6. Knowledge of the status of individuals at specific loci of these genes is useful in devising precision nutrition and other interventions that might contribute to preventing the development of AD. The intention is to streamline earlier diagnosis of AD which effectively leads to improved patient outcomes following pharmaceutical interventions. In developing this innovative technology to detect AD risk genes rapidly and accurately, revolutionizing the diagnostic process for the at-risk population.
