Grant: Op Gr: Innovative Biomedical and Clinical HIV/AIDS Research - New Investigators
University of Manitoba
$206,600.00
Elucidating the role of cell homing pathways in controlling endothelial cell-mediated enhancement of resting CD4+ T cell infection by HIV
FY 2016-17
Summary
Endothelial cells (ECs) line the vessels of our blood and lymphatic systems and direct traffic of immune cells between different tissues. ECs also enhance infection of HIV target cells that, on their own, resist HIV infection. However, the mechanisms behind this enhanced infection are unknown. This proposal aims to address this gap in knowledge by testing whether the molecules responsible for directing cell traffic are also responsible for enhancing cellular susceptibility to HIV infection. We will also look at changes in the genes expressed in both ECs and the HIV target cells, called CD4+ T cells, following interactions between the two cell types. This research will inform design of novel interventions that may block HIV infection and/or prevent disease progression in individuals who are already infected.
Department
Program
Op Gr: Innovative Biomedical and Clinical HIV/AIDS Research - New Investigators
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
366806
Name
Su Ruey-Chyi
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Innovative Biomedical and Clinical HIV/AIDS Research
Projecttitle
Elucidating the role of cell homing pathways in controlling endothelial cell-mediated enhancement of resting CD4+ T cell infection by HIV
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$206,600
Cihrequipment2
$0
Programname2
Op Gr: Innovative Biomedical and Clinical HIV/AIDS Research - New Investigators
Keyworddelim
Adhesion Molecules; Alpha4beta7; Cell Homing; Endothelial Cells; Gene Expression; Hiv Susceptibility; Hiv Target Cells; Mucosal Immunology; Resting Cd4+ T Cell; Rna-Seq
Abstract
Endothelial cells (ECs) line the vessels of our blood and lymphatic systems and direct traffic of immune cells between different tissues. ECs also enhance infection of HIV target cells that, on their own, resist HIV infection. However, the mechanisms behind this enhanced infection are unknown. This proposal aims to address this gap in knowledge by testing whether the molecules responsible for directing cell traffic are also responsible for enhancing cellular susceptibility to HIV infection. We will also look at changes in the genes expressed in both ECs and the HIV target cells, called CD4+ T cells, following interactions between the two cell types. This research will inform design of novel interventions that may block HIV infection and/or prevent disease progression in individuals who are already infected.
Competitiondate
201702
Approvedterm2
1 yr 6 mths
Pinamesdelim
Su, Ruey-Chyi
Approvedterm
1 an 6 mois
Cihrcontribution2
~ $206,600~ $0~
