Grant: CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Concordia University (Montreal, Quebec)
$70,000.00
Impact of Age of Obesity Onset and Weight Loss on Adipocyte Signalling in Breast Cancer Progression
FY 2025-26
Summary
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that is difficult to treat and increasingly affects younger women. Research suggests that belly fat cells can release signals that help breast cancer cells grow and spread, but these signals are not well understood. The age at which a person develops obesity, as well as whether they later lose weight, may influence these signals. In this study, we will examine how age of obesity onset affects communication between belly fat cells and TNBC cells, and whether weight loss alters this interaction. By comparing signals from individuals with childhood- versus adult- onset obesity, before and after weight loss, this research aims to support more personalized approaches to TNBC prevention and treatment.
Department
Program
CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
579827
Name
Santosa Sylvia
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Cancer Research Society Inc.; Cancer Research Society Inc.
Instname2
Cancer Research
Prcname2
Special Cases
Projecttitle
Impact of Age of Obesity Onset and Weight Loss on Adipocyte Signalling in Breast Cancer Progression
Programtype2
Operating Grants
Orgnameinp2
Concordia University (Montreal, Quebec)
Cihramount2
$70,000
Cihrequipment2
$0
Programname2
CIHR - ICR / Cancer Research Society Partnership - Res. Grants - Breast Cancer
Keyworddelim
Breast Cancer; Cell Signaling Pathways In Cancer; Translational Research; Tumour Progression And Metastasis
Abstract
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer that is difficult to treat and increasingly affects younger women. Research suggests that belly fat cells can release signals that help breast cancer cells grow and spread, but these signals are not well understood. The age at which a person develops obesity, as well as whether they later lose weight, may influence these signals. In this study, we will examine how age of obesity onset affects communication between belly fat cells and TNBC cells, and whether weight loss alters this interaction. By comparing signals from individuals with childhood- versus adult- onset obesity, before and after weight loss, this research aims to support more personalized approaches to TNBC prevention and treatment.
Competitiondate
202602
Approvedterm2
2 yrs 0 mth
Pinamesdelim
Santosa, Sylvia
Approvedterm
2 ans 0 mois
Cihrcontribution2
~ $70,000~ $0~
