Grant: Operating Grant
University of Toronto
$705,075.00
The impact of Nod proteins on the inflammatory response to differentially compartmentalized intracellular pathogens
FY 2009-10
Summary
Detection of microbes by the host is critical to initiate a program to develop inflammation, leading to the successful clearance of the infection. Specific receptors inside the host cell are critical for the initiation of this program. Our laboratory studies Nod1 and Nod2, which are key mediators of this intracellular surveillance system. In this proposal, we wish to explore the cellular mechanisms of how Nod proteins detect different invasive bacteria and how this impacts on the inflammatory program, and ultimately, recovery from infection.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
189709
Name
Philpott Dana J
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
The impact of Nod proteins on the inflammatory response to differentially compartmentalized intracellular pathogens
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$705,075
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cell Biology; Immunity; Infection; Inflammation; Inflammatory Bowel Disease
Abstract
Detection of microbes by the host is critical to initiate a program to develop inflammation, leading to the successful clearance of the infection. Specific receptors inside the host cell are critical for the initiation of this program. Our laboratory studies Nod1 and Nod2, which are key mediators of this intracellular surveillance system. In this proposal, we wish to explore the cellular mechanisms of how Nod proteins detect different invasive bacteria and how this impacts on the inflammatory program, and ultimately, recovery from infection.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Philpott, Dana J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $705,075~ $0~
