Grant: Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Memorial University of Newfoundland
$250,554.00
Identifying novel genes causing otosclerosis, the most common cause of progressive hearing loss in Caucasians worldwide, using Newfoundland's founder population.
FY 2009-10
Summary
Otosclerosis is a type of conductive hearing loss that affects adults in their 20s-30s and may progress to profound hearing loss. It is caused by abnormal overgrowth of the tiny bones in the middle ear, causing these normally mobile bones to "freeze". In some cases, this type of hearing loss runs in families and is passed on generation after generation. For a diagnosis of otosclerosis, a doctor (ears, nose and throat specialist) has to exclude all other diseases that may cause the progressive hearing loss s/he observes in the patient. If the diagnosis is correct, a surgical procedure (a stapedectomy) can completely restore hearing. Genetic studies are underway in families with otosclerosis to identify the genes causing the abnormal bone growth in order to provide a genetic test that can quickly provide an accurate diagnosis and patients who would benefit from surgery and to understand why it happens so preventative therapies can be developed.
Department
Program
Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
207295
Name
Young Terry-Lynn
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Partnername
Newfoundland and Labrador Research & Development Corp.
Instname2
Genetics
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
Identifying novel genes causing otosclerosis, the most common cause of progressive hearing loss in Caucasians worldwide, using Newfoundland's founder population.
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$250,554
Cihrequipment2
$0
Programname2
Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador
Keyworddelim
Family And Population Studies; Gene Mapping And Cloning; Gene-Gene Interactions; Genetics Of Deafness; Genotype-Phenotype Correlation; Isolated Population
Abstract
Otosclerosis is a type of conductive hearing loss that affects adults in their 20s-30s and may progress to profound hearing loss. It is caused by abnormal overgrowth of the tiny bones in the middle ear, causing these normally mobile bones to "freeze". In some cases, this type of hearing loss runs in families and is passed on generation after generation. For a diagnosis of otosclerosis, a doctor (ears, nose and throat specialist) has to exclude all other diseases that may cause the progressive hearing loss s/he observes in the patient. If the diagnosis is correct, a surgical procedure (a stapedectomy) can completely restore hearing. Genetic studies are underway in families with otosclerosis to identify the genes causing the abnormal bone growth in order to provide a genetic test that can quickly provide an accurate diagnosis and patients who would benefit from surgery and to understand why it happens so preventative therapies can be developed.
Competitiondate
201003
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Young, Terry-Lynn
Approvedterm
3 ans 0 mois
Cihrcontribution2
SPIR~ $250,554~ $0~
