Grant: CIHR-ICRH Travel Awards - General pool
McGill University
$1,480.00
D-Mannose Supplementation Attenuates Atherosclerotic Lesions in High Fat Diet Fed ApoE-/- Mice: Implications of Gut Microbiota Modulation.
FY 2023-24
Summary
D-mannose, a natural sugar, had previously shown promise in altering gut bacteria and preventing obesity. This study focused on whether it could also combat artery-clogging atherosclerosis. In mice genetically predisposed to artery problems, D-mannose was added to those on a high-fat diet. Strikingly, mice with D-mannose had fewer artery blockages. Notably, D-mannose appeared to reverse changes in gut bacteria caused by the high fat diet. In short, D-mannose might offer protection against artery issues, potentially tied to its influence on gut bacteria. These findings spotlight a novel avenue for promoting heart health.
Department
Program
CIHR-ICRH Travel Awards - General pool
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
495292
Name
O'Connor Miranda Jonathan A
Region
Québec
Country
Canada
Orgtype
Research Institution; Institution Paid
Prcname2
Special Cases
Projecttitle
D-Mannose Supplementation Attenuates Atherosclerotic Lesions in High Fat Diet Fed ApoE-/- Mice: Implications of Gut Microbiota Modulation.
Programtype2
Undefined
Orgnameinp2
McGill University
Cihramount2
$1,480
Cihrequipment2
$0
Programname2
CIHR-ICRH Travel Awards - General pool
Keyworddelim
D-Mannose
Abstract
D-mannose, a natural sugar, had previously shown promise in altering gut bacteria and preventing obesity. This study focused on whether it could also combat artery-clogging atherosclerosis. In mice genetically predisposed to artery problems, D-mannose was added to those on a high-fat diet. Strikingly, mice with D-mannose had fewer artery blockages. Notably, D-mannose appeared to reverse changes in gut bacteria caused by the high fat diet. In short, D-mannose might offer protection against artery issues, potentially tied to its influence on gut bacteria. These findings spotlight a novel avenue for promoting heart health.
Competitiondate
202309
Approvedterm2
1 yr 0 mth
Pinamesdelim
O'Connor Miranda, Jonathan A
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $1,480~ $0~
