Grant: Discovery Grants Program - Individual

The obsession over noble metal (Gold, Silver) nanoparticles predates modern science as they gave stained glass wonderful properties. Thousands of years later we find ourselves still obsessed, but today's researchers are focused on their controlled synthesis and understanding their structure and properties. The properties of gold/silver nanomaterials are determined mostly by their size that is controlled by the stabilizing ligands that surround the metal core. Modern efforts are aimed at designing new ligands for a desired application but synthesizing the nanoclusters often lead to changes in the size/properties. The @WorkentinChem Group's goals are to approach new nanocluster synthesis by designing and synthesizing ligands for the preparation of nanoclusters that contain a prosthetic group capable of efficient, quantitative, clickable, chemical reactions post-nanocluster synthesis to deliver new function with the properties on the preset nanocluster core. Reactions of molecules in solution are supported by a well-developed set of methods from physical organic chemistry, but the reactions of molecules at the interface of nanomaterials are not as well understood. Our studies examine factors that control the surface reactivity and molecular interactions in these unique nanomaterials. Understanding these factors is essential for the rationale design and control of these nanomaterials and for incorporating them into other functional materials. Our systems can undergo specific thermal, photo-, or electrochemical reactions in the interfacial material environment and provide new platforms for selective surface modifications. The importance lies in the recognition of the utility of these types of functional materials in the development of value-added products in nano-medicines, bio-imaging, drug delivery, molecular electronics, sensors, catalysis and other applications. The goals of this proposal are built on these foundational themes. We propose to:1) develop an interchangeable tool box of interfacial reactions that can be used to functionalize noble metal nanocluster materials rapidly, selectively, quantitatively, and under mild conditions; 2) develop strategies to make our technology transferable to a variety of materials; 3) exploit these reactions towards applications through effective collaboration within academia and industrial innovation contributors. To accomplish these goals, we also achieve our greatest impact on Canadian science, the training of diverse personnel who become the creative minds driving the future of Canadian science and innovation. These personnel master a broad spectrum of core chemical competencies in organic synthetic methods and analysis, inorganic and organic materials chemistry and the specialized techniques for their characterization as well as advanced skills in electrochemistry, photochemistry and materials chemistry. Trained HQP from my group have had a 100% professional placement over the last 18+ years.