Grant: Operating Grant
University of British Columbia
$1,139,616.00
Early childhood behavior: Relations to early brain structure/function and maternal mood
FY 2011-12
Summary
Mothers' mood disorders during pregnancy and the antidepressant medicines used to treat them appear to have effects on the developing baby and may contribute to childhood behavioral disturbances. The reasons that some children are affected and others are not remains unclear. In earlier work, we have shown that brain blood flow is altered in the fetus of pregnant women taking antidepressant medications called serotonin reuptake inhibitors (SRI). Owing to recent advances in magnetic resonance imaging (MRI) now provides us with the unique opportunity to understand if the changes in brain blood flow are associated with differences in early brain development and child behavior. To answer this question, we will study 3 groups of mothers and their children (depressed/SRI-treated; depressed/non-SRI-treated; and healthy controls) at 4 time points (36 weeks gestation; neonate day 2 and 6; age 24 months). We believe that our work will help us to understand more about very specific areas of early brain develop¬ment that shape child behavior and should lead to improved healthof these children and their mothers.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
238268
Name
Oberlander Timothy F
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Social & Developmental Aspects of Children's & Youth's Health
Projecttitle
Early childhood behavior: Relations to early brain structure/function and maternal mood
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$1,139,616
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Childhood Neurobehavior; Fetal Neurobehavioral Development; Infant Neurobehavior; Neuroimaging; Prenatal Antidepressant Exposure
Abstract
Mothers' mood disorders during pregnancy and the antidepressant medicines used to treat them appear to have effects on the developing baby and may contribute to childhood behavioral disturbances. The reasons that some children are affected and others are not remains unclear. In earlier work, we have shown that brain blood flow is altered in the fetus of pregnant women taking antidepressant medications called serotonin reuptake inhibitors (SRI). Owing to recent advances in magnetic resonance imaging (MRI) now provides us with the unique opportunity to understand if the changes in brain blood flow are associated with differences in early brain development and child behavior. To answer this question, we will study 3 groups of mothers and their children (depressed/SRI-treated; depressed/non-SRI-treated; and healthy controls) at 4 time points (36 weeks gestation; neonate day 2 and 6; age 24 months). We believe that our work will help us to understand more about very specific areas of early brain develop¬ment that shape child behavior and should lead to improved healthof these children and their mothers.
Competitiondate
201109
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Oberlander, Timothy F
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,139,616~ $0~
