Grant: Travel Awards - Institute Community Support

Kidney transplant is the only effective treatment for end-stage renal diseases, however, survival of a transplanted kidney is usually affected by acute kidney injury(AKI), which often happens in recipients post-transplant. AKI includes complicated renal changes, both in renal tubular compartment and renal vascular compartment, which are two major compartments in kidney. Among these renal changes, renal cell death has already been proved, in both tubular and vascular system. This project aims to understand the effect of classic cell death on renal function in AKI mice model and in renal cells model, by blocking one of the most common cell deaths---apoptosis. As a result, only renal vascular cells are rescued, while renal tubular cells find another way to die. In addition, rescued renal microvascular structure benefits long-term renal function, with reduced renal fibrosis and chronic renal dysfunction.