Grant: Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Memorial University of Newfoundland
$273,319.00
The Influence of Killer Cell Immunoglobulin-like Receptors and Their Ligands on HIV-specific CD8+ T Cell Function
FY 2008-09
Summary
Several recent studies have found that expression of certain combinations from within groups of genes referred to as histocompatibility-linked antigen (HLA) genes or killer cell immunoglobulin-like receptor (KIR) genes is associated with protection from HIV infection or with slow disease progression. Interactions between genes in these two families controls the function of natural killer cells and can also affect the function of T lymphocytes. We are testing the idea that T lymphocytes attacking the human immunodefiency virus (HIV) work more effectively if they express members of the KIR gene family that interact with HLA genes that the HIV-infected cells also express. If this idea were true, it would provide a mechanistic explanation for the genetic associations reported and introduce new strategies for vaccination against HIV.
Department
Program
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
177303
Name
Grant Michael D
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Virology & Viral Pathogenesis
Projecttitle
The Influence of Killer Cell Immunoglobulin-like Receptors and Their Ligands on HIV-specific CD8+ T Cell Function
Programtype2
Operating Grants
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$273,319
Cihrequipment2
$0
Programname2
Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream
Keyworddelim
Cd8; Hiv; Hla; Immunology; Kir; T Cell
Abstract
Several recent studies have found that expression of certain combinations from within groups of genes referred to as histocompatibility-linked antigen (HLA) genes or killer cell immunoglobulin-like receptor (KIR) genes is associated with protection from HIV infection or with slow disease progression. Interactions between genes in these two families controls the function of natural killer cells and can also affect the function of T lymphocytes. We are testing the idea that T lymphocytes attacking the human immunodefiency virus (HIV) work more effectively if they express members of the KIR gene family that interact with HLA genes that the HIV-infected cells also express. If this idea were true, it would provide a mechanistic explanation for the genetic associations reported and introduce new strategies for vaccination against HIV.
Competitiondate
200809
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Grant, Michael D
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $273,319~ $0~
