Grant: Operating Grant
McMaster University
$748,095.00
Novel Strategies to Enhance BCG Vaccine-induced Mucosal Immunity against Pulmonary Tuberculosis
FY 2010-11
Summary
Tuberculosis (TB) is a chronic destructive lung disease and remains one of the top infectious causes of death worldwide. While the current vaccine, BCG, is effective in protecting from disseminated forms of childhood TB, it fails to protect from pulmonary TB, the major global TB burden. There is an urgent need to understand the immune mechanisms underlying the failure of BCG vaccination and develop safe and effective strategies to enhance protective immunity by BCG. Built on the progress that we have made, our current proposal aims to investigate the mechanisms of BCG vaccine-induced lung mucosal immunity and develop novel strategies to improve such protective immunity against pulmonary TB in animal models. Our proposed studies will provide much needed knowledge and solutions for the fight against global TB epidemic.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
211557
Name
Xing Zhou
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
Novel Strategies to Enhance BCG Vaccine-induced Mucosal Immunity against Pulmonary Tuberculosis
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$748,095
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Destructive Lung Disease; Lung Inflammation; Lung Mucosal Immunity; Pulmonary Tuberculosis; T Cell Responses; Vaccination
Abstract
Tuberculosis (TB) is a chronic destructive lung disease and remains one of the top infectious causes of death worldwide. While the current vaccine, BCG, is effective in protecting from disseminated forms of childhood TB, it fails to protect from pulmonary TB, the major global TB burden. There is an urgent need to understand the immune mechanisms underlying the failure of BCG vaccination and develop safe and effective strategies to enhance protective immunity by BCG. Built on the progress that we have made, our current proposal aims to investigate the mechanisms of BCG vaccine-induced lung mucosal immunity and develop novel strategies to improve such protective immunity against pulmonary TB in animal models. Our proposed studies will provide much needed knowledge and solutions for the fight against global TB epidemic.
Competitiondate
201009
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Xing, Zhou
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $748,095~ $0~
