Grant: Project Grant - PA: Arthritis
Centre hospitalier de l'Université de Montréal (CHUM)
$100,000.00
Role of 15-Lipoxygenases in Osteoarthritis
FY 2019-20
Summary
Osteoarthritis is the most prevalent musculoskeletal disorder, and the leading cause of disability in Canada and worldwide The impact of this disease is expected to increase dramatically as a result of increased life expectancy and population aging.
Osteoarthritis is characterized by cartilage degradation, synovial inflammation, bony changes, and chronic pain. So far, there is no efficient treatment for Osteoarthritis.
Our recent studies strongly suggest that the 15-Lipoxygenase and its products LXA4 has protective effects in osteoarthritis. In this project we will extend these findings. We will perform studies in vitro with cells, in animal models of osteoarthritis and with human tissues to further characterize the role of this axis in Osteoarthritis.
These studies will improve our understanding of the pathogenesis of Osteoarthritis and will be very helpful in developing more efficient therapeutic strategies for the treatment of Osteoarthritis and possibly other musculoskeletal disorders.
Department
Program
Project Grant - PA: Arthritis
Location
Quebec, Canada
Recipient Type
Not-for-profit organization or charity
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
414177
Name
Fahmi Hassan
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Musculoskeletal Health and Arthritis
Theme2
Biomedical
Prcname2
Clinical Investigation - B: Arthritis, Bone, Skin and Cartilage
Projecttitle
Role of 15-Lipoxygenases in Osteoarthritis
Programtype2
Operating Grants
Orgnameinp2
Centre hospitalier de l'Université de Montréal (CHUM)
Cihramount2
$100,000
Cihrequipment2
$0
Programname2
Project Grant - PA: Arthritis
Keyworddelim
15-Lipoxygenase; Cartilage; Dna Methylation; Histones; Lxa4; Osteoarthritis
Abstract
Osteoarthritis is the most prevalent musculoskeletal disorder, and the leading cause of disability in Canada and worldwide The impact of this disease is expected to increase dramatically as a result of increased life expectancy and population aging.
Osteoarthritis is characterized by cartilage degradation, synovial inflammation, bony changes, and chronic pain. So far, there is no efficient treatment for Osteoarthritis.
Our recent studies strongly suggest that the 15-Lipoxygenase and its products LXA4 has protective effects in osteoarthritis. In this project we will extend these findings. We will perform studies in vitro with cells, in animal models of osteoarthritis and with human tissues to further characterize the role of this axis in Osteoarthritis.
These studies will improve our understanding of the pathogenesis of Osteoarthritis and will be very helpful in developing more efficient therapeutic strategies for the treatment of Osteoarthritis and possibly other musculoskeletal disorders.
Competitiondate
201909
Approvedterm2
1 yr 0 mth
Pinamesdelim
Fahmi, Hassan
Approvedterm
1 an 0 mois
Cihrcontribution2
~ $100,000~ $0~
